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Facts moms and teens should know.

Meningococcal group B disease (also known as meningitis B) is an uncommon but serious disease that is caused by a bacterial infection of the lining of the brain and spinal cord. It can also cause a severe infection of the blood called meningococcal septicemia.

Meningitis B strikes and progresses quickly – sometimes without warning – and can be fatal, sometimes within 24 hours. Some survivors will have long-term physical and cognitive disabilities, including brain damage, hearing loss and loss of limbs.

The bacteria that cause meningitis B live within the nose and throat and can be spread through close contact such as coughing, kissing or sneezing.

Certain everyday behaviors can increase the risk of getting meningitis B, particularly for teens and young adults, including:

Living in close quarters

Sharing drinks and eating utensils

Coughing and sneezing

Kissing

*In rare cases, the bacteria can invade the body and lead to meningococcal disease.

Initial symptoms may be mild, which is why people might confuse the early signs with the flu or a cold. However, symptoms can progress rapidly and can lead to death, sometimes within 24 hours.

Symptoms may include:

Sudden fever

Headache

Stiff neck

Additional symptoms may include nausea, vomiting, sensitivity of the eyes to light, confusion, and a rash (typically dark purple spots on the torso, arms, or legs).

If you are experiencing these symptoms or if you have been in close contact with someone who has meningitis, please contact your healthcare professional immediately.

Meningitis B is unpredictable. Individual cases happen from time to time across the country, mostly in (but not limited to) high school, college, and military barracks settings. Occasionally, outbreaks do occur.

From January 2015 to November 2016, there were 18 cases, including one death, of meningitis B at colleges or universities in the following states: Rhode Island, California, New Jersey, Wisconsin, and Oregon.

Moms are getting the word out against meningitis B. Teens are getting BEXSERO.

Ask your teen's healthcare professional if vaccination with BEXSERO is right for them.

FIND OUT WHERE TO GET BEXSERO

Important Safety Information About BEXSERO Important Safety Information About BEXSERO

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Citation: Han Y. 2011. Fusobacterium nucleatum Interaction with Host Cells, p 221-232. Kolenbrander P (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555817107.ch15
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/content/10.1128/9781555817107.ch15.ch15fig03
FIGURE 3
Amino acid sequence of FadA in one-letter code. The underlined residues encode the signal peptide, followed by mFadA. The central hairpin residues TRFY are marked by dotted lines, the leucine residues are marked by asterisks, and the histidine tag at the C terminus is italicized. Reproduced from J. Biol. Chem. ( 61 ) with permission.
10.1128/9781555817107/f0225-01_thmb.gif
10.1128/9781555817107/f0225-01.gif

Amino acid sequence of FadA in one-letter code. The underlined residues encode the signal peptide, followed by mFadA. The central hairpin residues TRFY are marked by dotted lines, the leucine residues are marked by asterisks, and the histidine tag at the C terminus is italicized. Reproduced from J. Biol. Chem. ( 61 ) with permission.

Citation: Han Y. 2011. Fusobacterium nucleatum Interaction with Host Cells, p 221-232. Kolenbrander P (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555817107.ch15
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/content/10.1128/9781555817107.ch15.ch15fig04
FIGURE 4
Amino acid sequence alignment of FadA and its paralogues. Highlighted in gray are the identical residues shared among FadA. The sequences of three FadA paralogues, FNN1529 from F. nucleatum ATCC 25586, FNV2159 from F. nucleatum ATCC 49256, and FNP1049 from F. nucleatum ATCC 10953, are listed below the FadA sequence. The conserved and identical residues among FadA and the paralogues are indicated. Fn, F. nucleatum ; Fp, F. periodonticum ; Fs, F. simiae. The numbers above the sequence indicate amino acid positions in the secreted form of FadA, and the numbers beside the sequence indicate positions in the intact form. Reproduced from Journal of Bacteriology ( DENIM Denim shirts ROY ROGERS PAROSH Buy Cheap Manchester Great Sale wTBnMEd
) with permission.
10.1128/9781555817107/f0226-01_thmb.gif
10.1128/9781555817107/f0226-01.gif

Amino acid sequence alignment of FadA and its paralogues. Highlighted in gray are the identical residues shared among FadA. The sequences of three FadA paralogues, FNN1529 from F. nucleatum ATCC 25586, FNV2159 from F. nucleatum ATCC 49256, and FNP1049 from F. nucleatum ATCC 10953, are listed below the FadA sequence. The conserved and identical residues among FadA and the paralogues are indicated. Fn, F. nucleatum ; Fp, F. periodonticum ; Fs, F. simiae. The numbers above the sequence indicate amino acid positions in the secreted form of FadA, and the numbers beside the sequence indicate positions in the intact form. Reproduced from Journal of Bacteriology ( 28 ) with permission.

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